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Poster De Conférence Année : 2015

Synthesis and evaluation of β-hydroxytriazoles and related compounds as antitubercular agents

Résumé

A new series of β-hydroxytriazoles were synthesized and evaluated as Mycobacterium tuberculosis inhibitors. Our strategy implied the synthesis of alkyne precursors through a Barbier reaction between benzaldehydes and propargyl bromide followed by click chemistry to afford substituted β-hydroxyl benzyltriazoles. These compounds are also key intermediates either for oxidation reactions leading to α,β-diketotriazoles or for elimination reactions affording styryl triazoles. Evaluation of all new compounds for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv resulted in compounds with MIC up to 7 μM.

Domaines

Chimie

Dates et versions

hal-03969265 , version 1 (02-02-2023)

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Citer

Christophe Menendez, Giorgia Mori, Mathilde Maillot, Isabelle Fabing, Chantal Carayon, et al.. Synthesis and evaluation of β-hydroxytriazoles and related compounds as antitubercular agents. 8th International Chemistry Conference Toulouse-Kiev (ICTK-8), ., Jun 2015, Toulouse, France. 3 (1), pp.82-96, 2015, ⟨10.17721/fujcv3i1p82-96⟩. ⟨hal-03969265⟩
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