Vexitoxins: conotoxin-like venom peptides from predatory gastropods of the genus Vexillum - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the Royal Society B: Biological Sciences Année : 2022

Vexitoxins: conotoxin-like venom peptides from predatory gastropods of the genus Vexillum

Ksenia Kuznetsova
  • Fonction : Auteur
Sofia Zvonareva
  • Fonction : Auteur
Rustam Ziganshin
  • Fonction : Auteur
Elena Mekhova
Polina Dgebuadze
  • Fonction : Auteur
Dinh Yen
  • Fonction : Auteur
Thanh Nguyen
  • Fonction : Auteur
Sergei Moshkovskii
  • Fonction : Auteur

Résumé

Venoms of predatory marine cone snails are intensely studied because of the biomedical applications of the neuropeptides that they contain, termed conotoxins. Meanwhile some gastropod lineages have independently acquired secretory glands strikingly similar to the venom gland of cone snails, suggesting that they possess similar venoms. Here we focus on the most diversified of these clades, the genus Vexillum . Based on the analysis of a multi-species proteo-transcriptomic dataset, we show that Vexillum species indeed produce complex venoms dominated by highly diversified short cysteine-rich peptides, vexitoxins. Vexitoxins possess the same precursor organization, display overlapping cysteine frameworks and share several common post-translational modifications with conotoxins. Some vexitoxins show sequence similarity to conotoxins and adopt similar domain conformations, including a pharmacologically relevant inhibitory cysteine knot motif. The Vexillum envenomation gland (gL) is a notably more recent evolutionary novelty than the conoidean venom gland. Thus, we hypothesize lower divergence between vexitoxin genes, and their ancestral ‘somatic’ counterparts compared to that in conotoxins, and we find support for this hypothesis in the evolution of the vexitoxin cluster V027. We use this example to discuss how future studies on vexitoxins can inform the origin of conotoxins, and how they may help to address outstanding questions in venom evolution.

Dates et versions

hal-03950260 , version 1 (21-01-2023)

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Citer

Ksenia Kuznetsova, Sofia Zvonareva, Rustam Ziganshin, Elena Mekhova, Polina Dgebuadze, et al.. Vexitoxins: conotoxin-like venom peptides from predatory gastropods of the genus Vexillum. Proceedings of the Royal Society B: Biological Sciences, 2022, 289 (1980), ⟨10.1098/rspb.2022.1152⟩. ⟨hal-03950260⟩
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