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Article Dans Une Revue (Data Paper) Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2022

Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease

Résumé

Introduction: This increasing body of literature indicates that menopause hormonal replacement therapy (MHT) may substantially mitigate the risk of developing late-life cognitive decline due to progressive Alzheimer's disease (AD) pathophysiology. For the first time, we investigated the question whether MHT impacts AD biomarker-informed pathophysiological dynamics in de-novo diagnosed menopausal women. Methods: We analyzed baseline and longitudinal differences between MHT-taking and-not women in terms of concentrations of core pathophysiological AD plasma biomarkers, validated in symptomatic and cognitively healthy individuals, including biomarkers of (1) the amyloid-β (Aβ) pathway, (2) tau pathophysiology, (3) neuronal loss, and (4) axonal damage and neurodegeneration. Results: We report a prominent and significant treatment response at the Aβ pathway biomarker level. Women at genetic risk for AD (APOE e4 allele carriers) have particularly shown favorable results from treatment. Discussion: To our knowledge, we present first prospective clinical evidence on effects of MHT on AD pathophysiology during menopause.
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Dates et versions

hal-03942258 , version 1 (17-01-2023)

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Herman Depypere, Andrea Vergallo, Pablo Lemercier, Simone Lista, Andrea Benedet, et al.. Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, ⟨10.1002/alz.12759⟩. ⟨hal-03942258⟩
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