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Article Dans Une Revue Nature Communications Année : 2019

The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization

D. Barrière
R. Magalhães
  • Fonction : Auteur
A. Novais
  • Fonction : Auteur
P. Marques
  • Fonction : Auteur
E. Selingue
  • Fonction : Auteur
F. Geffroy
  • Fonction : Auteur
F. Marques
  • Fonction : Auteur
J. Cerqueira
J. Sousa
  • Fonction : Auteur
F. Boumezbeur
  • Fonction : Auteur
M. Bottlaender
T. Jay
  • Fonction : Auteur
N. Sousa
S. Mériaux

Résumé

Abstract Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo $${\mathrm{T}}_2^ \ast$$ T 2 * -weighted images (90 µm isotropic resolution) and in vivo T 2 -weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.

Dates et versions

hal-03936722 , version 1 (12-01-2023)

Identifiants

Citer

D. Barrière, R. Magalhães, A. Novais, P. Marques, E. Selingue, et al.. The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization. Nature Communications, 2019, 10 (1), pp.5699. ⟨10.1038/s41467-019-13575-7⟩. ⟨hal-03936722⟩
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