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Journal Articles RSC Chemical Biology Year : 2022

Photo-induced telomeric DNA damage in human cancer cells

Abstract

Herein we report on the study of novel dinuclear ruthenium(II) complexes designed to target and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently generate guanine radical cation sites as photo-oxidation products. The compounds also display efficient cell penetration with localization to the nucleus and show strong photocytotoxicity toward osteosarcoma cells. Thanks to a microscopic-based telomere dysfunction assay, which allows the direct visualization of DNA damage in cells, we brought the first evidence of forming photo-oxidative damage at telomeres in cellulo. This emphasizes interesting prospects for the development of future cancer phototherapies.
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Dates and versions

hal-03933122 , version 1 (10-01-2023)

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Attribution - NonCommercial

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Justin Weynand, Harikleia Episkopou, Gabriel Le Berre, Martin Gillard, Jérôme Dejeu, et al.. Photo-induced telomeric DNA damage in human cancer cells. RSC Chemical Biology, 2022, 3, pp.1375 - 1379. ⟨10.1039/d2cb00192f⟩. ⟨hal-03933122⟩
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