Neolithic human societies settled in Brittany erected numerous megalithic monuments. In North-Brittany (France) the Bay of Goulven appears to be a key area to understand coastal socio-environmental trajectories since an important concentration of gallery graves, erected during the Recent and Late Neolithic, testifies to a high population density. To shed new light on environmental and anthropogenic dynamics, a multidisciplinary approach mobilizing sedimentological, palynological and ancient DNA analyses was implemented on twin sedimentary cores, covering the last 7 kyrs BP and retrieved in the coastal wetland closed to Plouescat locality. Preliminary results of XRF and palynological analyses display a progressive sedimentary infilling of the former maritime marsh up to a continental area totally disconnected from the marine influence at 5.4 ka BP. Superimposed to this environmental context, the first obvious, but tenuous anthropogenic markers occur from 6.8 to 5 Ka BP, before disappearing up to 4.7 ka BP. This 300-years period corresponds to a potential abandonment of this coastal area before a new anthropogenic influence arises from 4.7 ka BP, and gradually increases reaching its climax at 2.4 ka BP (i.e., Second Iron Age). There are still open questions about the identification of anthropic activities in coastal environments. The low taphonomic resolution of Anthropogenic Pollen Indicators (API; i.e., ruderal, adventitious or cultivated taxa) together with the poor dispersion capacities of crops far from production areas limit the expression of anthropogenic activities in the pollen signal. The next step of this study is to combine the extracellular DNA preserved in sediments, detecting DNA markers of domestic mammals and anthropogenic plant groups, with palynological approaches to accurate the history of the local agro-pastoral practices.