Article Dans Une Revue Blood Année : 2012

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations

Iléana Antony-Debré
  • Fonction : Auteur
Dominique Bluteau
Raphael Itzykson
  • Fonction : Auteur
Aline Renneville
  • Fonction : Auteur
Françoise Boehlen
  • Fonction : Auteur
Margot Morabito
  • Fonction : Auteur
Nathalie Droin
  • Fonction : Auteur
Caroline Deswarte
  • Fonction : Auteur
Yunhua Chang
  • Fonction : Auteur
Guy Leverger
  • Fonction : Auteur
Eric Solary
  • Fonction : Auteur
William Vainchenker
Rémi Favier
  • Fonction : Auteur
Hana Raslova
  • Fonction : Auteur

Résumé

Abstract RUNX1 gene alterations are associated with acquired and inherited hematologic malignancies that include familial platelet disorder/acute myeloid leukemia, primary or secondary acute myeloid leukemia, and chronic myelomonocytic leukemia. Recently, we reported that RUNX1-mediated silencing of nonmuscle myosin heavy chain IIB (MYH10) was required for megakaryocyte ploidization and maturation. Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. MYH10 was also detected in platelets of patients with the Paris-Trousseau syndrome, a thrombocytopenia related to the deletion of the transcription factor FLI1 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not observed in other inherited forms of thrombocytopenia. We propose MYH10 detection as a new and simple tool to identify inherited platelet disorders and myeloid neoplasms with abnormalities in RUNX1 and its associated proteins.

Dates et versions

hal-03905363 , version 1 (18-12-2022)

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Citer

Iléana Antony-Debré, Dominique Bluteau, Raphael Itzykson, Véronique Baccini, Aline Renneville, et al.. MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations. Blood, 2012, 120 (13), pp.2719-2722. ⟨10.1182/blood-2012-04-422352⟩. ⟨hal-03905363⟩
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