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Article Dans Une Revue Bulletin de l'Académie Vétérinaire de France Année : 2022

RETINOPATHY IN THE BORDER COLLIE, AN INHERITED DISEASE BUT A GENE THAT IS DIFFICULT TO MAP

LA RÉTINOPATHIE DU BORDER COLLIE, UNE MALADIE HÉRÉDITAIRE MAIS UN GÈNE DIFFICILE A ISOLER

Résumé

Some Border Collies, essentially males on average 4-year-old, exhibit focal or generalized retinal atrophic lesions. A following survey revealed progressive lesions and histopathology examination confirmed retinal degeneration. The hypothesis of a X-linked inheritance is supported by a genetic linkage study highlighting the X chromosome. Whole genome sequencing (« short read ») of several dogs identifies variants segregating as expected. The « long read » would allow the identification of structural variants. Variability in the phenotype might induce difficulties to point out common variants in affected dogs. Thus, a strict selection of the cases has been performed. In addition, the selection of breeding dogs on the basis of the X-linked inheritance by the French Border Collie Kennel Club enabled to decrease the frequency of the affected dogs from 20% (2001) to 7,4% (2019). © 2022 Academie Veterinaire de France. All rights reserved.

Dates et versions

hal-03899058 , version 1 (14-12-2022)

Identifiants

Citer

P.G. Chaudieu, P. Quignon. LA RÉTINOPATHIE DU BORDER COLLIE, UNE MALADIE HÉRÉDITAIRE MAIS UN GÈNE DIFFICILE A ISOLER. Bulletin de l'Académie Vétérinaire de France, 2022, 175, ⟨10.3406/bavf.2022.71060⟩. ⟨hal-03899058⟩
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