Herbicide use in farming and other jobs in relation to non-Hodgkin's lymphoma (NHL) risk
Anneclaire J. de Roos
(1)
,
Lin Fritschi
(2)
,
Mary H. Ward
(3)
,
Alain Monnereau
(4, 5)
,
Jonathan Hofmann
(3)
,
Leslie Bernstein
(6)
,
Parveen Bhatti
(7)
,
Yolanda Benavente Moreno
(8, 9)
,
Geza Benke
(10)
,
Delphine Casabonne
(8, 9)
,
Jacqueline Clavel
(5)
,
Pierluigi Cocco
(11, 12)
,
Tran Huynh
(1)
,
Andrea T Mannetje
(13)
,
Lucia Miligi
(14)
,
Sara Piro
(14)
,
Nathaniel Rothman
(3)
,
Leah H. Schinasi
(1)
,
Claire M. Vajdic
(15)
,
Sophia S. Wang
(6)
,
Yawei Zhang
(16)
,
Susan L. Slager
(17)
,
James R. Cerhan
(17)
1
Drexel University
2 Curtin University
3 NCI-NIH - National Cancer Institute [Bethesda]
4 Institut Bergonié [Bordeaux]
5 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
6 City of Hope Comprehensive Cancer Center [Duarte]
7 BCCRC - BC Cancer Agency Research Centre
8 L’Hospitalet de Llobregat [Barcelona, Spain]
9 ISC - Instituto de Salud Carlos III [Madrid]
10 Monash University [Melbourne]
11 University of Manchester [Manchester]
12 UniCa - Università degli Studi di Cagliari = University of Cagliari
13 Massey University
14 ISPRO - Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
15 UNSW - University of New South Wales
16 Peking Union Medical College [Beijing, China]
17 Mayo Clinic [Rochester]
2 Curtin University
3 NCI-NIH - National Cancer Institute [Bethesda]
4 Institut Bergonié [Bordeaux]
5 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
6 City of Hope Comprehensive Cancer Center [Duarte]
7 BCCRC - BC Cancer Agency Research Centre
8 L’Hospitalet de Llobregat [Barcelona, Spain]
9 ISC - Instituto de Salud Carlos III [Madrid]
10 Monash University [Melbourne]
11 University of Manchester [Manchester]
12 UniCa - Università degli Studi di Cagliari = University of Cagliari
13 Massey University
14 ISPRO - Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
15 UNSW - University of New South Wales
16 Peking Union Medical College [Beijing, China]
17 Mayo Clinic [Rochester]
Résumé
OBJECTIVES: Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin's lymphoma (NHL) in a large, pooled study. METHODS: We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides. RESULTS: We found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses. CONCLUSIONS: Most of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks.
Domaines
Santé publique et épidémiologieFormat du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Herbicide use in farming and other jobs in relation to non-Hodgkin's lymphoma (NHL) risk
|
Résumé |
en
OBJECTIVES: Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin's lymphoma (NHL) in a large, pooled study. METHODS: We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides. RESULTS: We found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses. CONCLUSIONS: Most of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks.
|
Auteur(s) |
Anneclaire J. de Roos
1
, Lin Fritschi
2
, Mary H. Ward
3
, Alain Monnereau
4, 5
, Jonathan Hofmann
3
, Leslie Bernstein
6
, Parveen Bhatti
7
, Yolanda Benavente Moreno
8, 9
, Geza Benke
10
, Delphine Casabonne
8, 9
, Jacqueline Clavel
5
, Pierluigi Cocco
11, 12
, Tran Huynh
1
, Andrea T Mannetje
13
, Lucia Miligi
14
, Sara Piro
14
, Nathaniel Rothman
3
, Leah H. Schinasi
1
, Claire M. Vajdic
15
, Sophia S. Wang
6
, Yawei Zhang
16
, Susan L. Slager
17
, James R. Cerhan
17
1
Drexel University
( 11333 )
- 3141 Chestnut Street, Philadelphia, PA 19104
- États-Unis
2
Curtin University
( 464746 )
- Address: Kent Street, Bentley Western Australia, 6102 / Postal address: GPO Box U1987, Perth Western Australia, 6845
- Australie
3
NCI-NIH -
National Cancer Institute [Bethesda]
( 305678 )
- BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760
- États-Unis
4
Institut Bergonié [Bordeaux]
( 28493 )
- 229, cours de l'Argonne - 33076 Bordeaux
- France
5
CRESS (U1153 / UMR_A 1125) -
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
( 1002409 )
- Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris
- France
6
City of Hope Comprehensive Cancer Center [Duarte]
( 500491 )
- 1500 East Duarte Road
Duarte, CA 91010, USA
- États-Unis
7
BCCRC -
BC Cancer Agency Research Centre
( 495622 )
- Canada
8
L’Hospitalet de Llobregat [Barcelona, Spain]
( 527532 )
- Espagne
9
ISC -
Instituto de Salud Carlos III [Madrid]
( 308343 )
- Carretera de Majadahonda - Pozuelo, 28220 Majadahonda, Madrid, Espagne
- Espagne
10
Monash University [Melbourne]
( 469589 )
- Victoria 3800, Australia
- Australie
11
University of Manchester [Manchester]
( 121172 )
- Oxford Rd, Manchester M13 9PL
- Royaume-Uni
12
UniCa -
Università degli Studi di Cagliari = University of Cagliari
( 204422 )
- Via Università, 40 - 09124 Cagliari
- Italie
13
Massey University
( 226209 )
- Palmerston North, Auckland (Albany), Wellington, New Zealand
- Nouvelle-Zélande
14
ISPRO -
Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
( 578717 )
- Via Cosimo Il Vecchio 2 - 50139 Firenze
- Italie
15
UNSW -
University of New South Wales
( 549768 )
- Australie
16
Peking Union Medical College [Beijing, China]
( 545960 )
- Beijing 100730.
- Chine
17
Mayo Clinic [Rochester]
( 157897 )
- 200 First St. SW
Rochester, MN 55905
- États-Unis
|
Page/Identifiant |
795-806
|
Volume |
79
|
Numéro |
12
|
Vulgarisation |
Non
|
Audience |
Internationale
|
Licence |
Paternité - Pas d'utilisation commerciale
|
Langue du document |
Anglais
|
Nom de la revue |
|
Comité de lecture |
Oui
|
Date de publication |
2022-10-07
|
Domaine(s) |
|
Mots-clés |
en
Epidemiology, Occupational health, Pesticides
|
DOI | 10.1136/oemed-2022-108371 |
Pubmed Id | 36207110 |
PubMed Central | PMC9669193 |
Origine :
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