Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Materials Today Chemistry Année : 2022

Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Résumé

Dendrimers, by virtue of their unique well-defined dendritic structure and multivalent cooperativity, hold great promise for a wide variety of applications, ranging from healthcare to energy production and environmental sustainability. However, dendrimer synthesis suffers from two inherent problems which greatly handicap their development and limit their application: the formation of structural defects caused by incomplete or side reactions, and difficulties associated with purification. Solid-phase synthesis may overcome both these problems, firstly by enabling complete chemical reactions through the use of a large excess of reagents, secondly by facilitating purification through simple washing and filtering steps. The end result is the speeded up reactions producing the desired product in high yield, with simultaneous suppression of by-products. In this review, we present the challenges and current state of research in solid-phase dendrimer synthesis, and provide our perspectives on its future development. We start with a short introduction to solid-phase synthesis and specific considerations for dendrimer construction. We then present exemplary studies to highlight the potential of, and challenges faced by, solid-phase dendrimer synthesis. Finally, we describe efforts to deliver more effective and reliable methods that will transform the synthesis of dendrimers and permit exploitation of their full potential.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
2022 MaterTodayChem HUANG.pdf (4.96 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03878638 , version 1 (29-11-2022)

Licence

Paternité

Identifiants

Citer

Ya-Ting Huang, C.-L Kao, A Selvaraj, Ling Peng. Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction. Materials Today Chemistry, 2022, ⟨10.1016/j.mtchem.2022.101285⟩. ⟨hal-03878638⟩
21 Consultations
111 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More