Development of Cu( ii )-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells
Résumé
The synthetic peptide AKH-αR5W4 NBD was designed as a shuttle to counteract copper imbalance in Alzheimer’s disease. In vitro , this shuttle is able to abstract Cu( ii ) selectively from amyloid-β and transport it into cells in a bioavailable form.
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