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Article Dans Une Revue Biometrical Journal Année : 2019

Bayesian knowledge integration for an in vitro–in vivo correlation model

Elvira Erhardt
Moreno Ursino
Jeike Biewenga
  • Fonction : Auteur
Tom Jacobs
  • Fonction : Auteur
Mauro Gasparini

Résumé

The primary goal of “in vitro–in vivo correlation” (IVIVC) is the reliable prediction of the in vivo serum concentration-time course, based on the in vitro drug dissolution or release profiles. IVIVC methods are particularly appropriate for formulations that are released over an extended period of time or with a lag in absorption and may support approving a change in formulation of a drug without additional bioequivalence trials in human subjects. Most of the current IVIVC models are assessed using frequentistmethods, such as linear regression, based on averaged data and entail complex and potentially unstable mathematical deconvolution. The proposed IVIVC approach includes (a) a nonlinear-mixed effects model for the in vitro release data; (b) a population pharmacokinetic (PK) compartment model for the in vivo immediate release (IR) data; and (c) a system of ordinal differential equations (ODEs), containing the submodels (a) and (b), which approximates and predicts the in vivo controlled release (CR) data. The innovation in this paper consists of splitting the parameter space between submodels (a) and (b) versus (c). Subsequently, the uncertainty on these parameters is accounted for using a Bayesian framework, that is estimates from the first two submodels serve as priors for the Bayesian hierarchical third submodel. As such, the Bayesian method explained ensures a natural integration and transfer of knowledge between various sources of information, balancing possible differences in sample size and parameter uncertainty of in vitro and in vivo studies. Consequently, it is a very flexible approach yielding results for a broad range of data situations. The application of the method is demonstrated for a transdermal patch (TD).
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Dates et versions

hal-03873774 , version 1 (27-11-2022)

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Elvira Erhardt, Moreno Ursino, Jeike Biewenga, Tom Jacobs, Mauro Gasparini. Bayesian knowledge integration for an in vitro–in vivo correlation model. Biometrical Journal, 2019, 61 (5), pp.1104-1119. ⟨10.1002/bimj.201700263⟩. ⟨hal-03873774⟩
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