Sustainable development is a concept of development that meets the needs of the present without compromising the ability to meet the needs of future generations. A sustainable model must therefore ensure a balance between economic, environmental and social impacts. This chapter examines how industrial cyber-physical systems (ICPS) have characteristics that contribute to solving these sustainable development challenges. The advantages of ICPS in favor of humans will be found in the different categories of aspects: the cognitive aspects, and the occupational health and safety aspects. The concept of ICPS is relevant to reduce environmental impacts within the industrial environment. Indeed, the cyber layer makes it possible to retrieve data in real time and extract useful information in the environmental component. Because of their ability to adapt quickly, optimize and integrate the various information systems, ICPS clearly contribute to the economic dimension of companies.