One-pot synthesis of dihydropyrimidines via eco-friendly phosphorus derivatives catalysis - Archive ouverte HAL
Article Dans Une Revue Journal of Saudi Chemical Society Année : 2022

One-pot synthesis of dihydropyrimidines via eco-friendly phosphorus derivatives catalysis

Résumé

A straightforward, cost effective and eco-friendly protocol for the Biginelli reaction relying on the use of readily available hypophosphorous acid is presented. The methodology developed displays improvements compared to existing methods, is high-yielding, robust and was applied to a panel of dihydropyrimidines and thio-derivatives with various substituents. Related urea derivatives such as guanidines, benzimidazoles and benzothiazoles also reacted efficiently to afford more complex scaffolds. Thus, this rapid and convenient catalysis allows access to a wide diversity of structures including original biologically relevant heterocycles.
Fichier principal
Vignette du fichier
S1319610321002039.pdf (209.94 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03870811 , version 1 (08-01-2024)

Licence

Identifiants

Citer

Zakaria Moutaoukil, Cyril Ronco, Rachid Benhida. One-pot synthesis of dihydropyrimidines via eco-friendly phosphorus derivatives catalysis. Journal of Saudi Chemical Society, 2022, 26 (1), pp.101398. ⟨10.1016/j.jscs.2021.101398⟩. ⟨hal-03870811⟩
18 Consultations
32 Téléchargements

Altmetric

Partager

More