Safeguarding DNA Replication: A Golden Touch of MiDAS and Other Mechanisms - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Safeguarding DNA Replication: A Golden Touch of MiDAS and Other Mechanisms

Résumé

DNA replication is a tightly regulated fundamental process allowing the correct duplication and transfer of the genetic information from the parental cell to the progeny. It involves the coordinated assembly of several proteins and protein complexes resulting in replication fork licensing, firing and progression. However, the DNA replication pathway is strewn with hurdles that affect replication fork progression during S phase. As a result, cells have adapted several mechanisms ensuring replication completion before entry into mitosis and segregating chromosomes with minimal, if any, abnormalities. In this review, we describe the possible obstacles that a replication fork might encounter and how the cell manages to protect DNA replication from S to the next G1.
Fichier principal
Vignette du fichier
ijms-23-11331-2.pdf (2.02 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-03862560 , version 1 (17-10-2023)

Identifiants

Citer

Baraah Al Ahmad Nachar, Filippo Rosselli. Safeguarding DNA Replication: A Golden Touch of MiDAS and Other Mechanisms. International Journal of Molecular Sciences, 2022, 23 (19), pp.11331. ⟨10.3390/ijms231911331⟩. ⟨hal-03862560⟩
12 Consultations
12 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More