Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study
Guillaume Geri
,
Bénédicte Stengel
,
Christian Jacquelinet
,
Philippe Aegerter
,
Ziad Massy
,
Antoine Vieillard-Baron
,
Stéphane Legriel
,
Virginie Laurent
,
Jean-Louis Teboul
,
Anatole Virginie Tarazona
,
Armand Mekontso-Dessap
,
Jean-Paul Mira
,
Jean-Luc Diehl
,
Romain Pirracchio
,
Naike Bigé
,
Claire Dupuis
,
Stéphane Gaudry
,
Julien Maizel
,
Bertrand Souweine
,
Lara Zafrani
,
Bruno Mégarbane
(1)
,
Alexandre Mebazaa
,
Antoine Durbach
,
Vincent Audard
,
Eric Thervet
,
Jean-Jacques Boffa
,
Guillaume Hanouna
,
Dimitri Titeca
,
Carole Philiponnet
,
Denis Glotz
Guillaume Geri
- Fonction : Auteur
- PersonId : 1145340
- ORCID : 0000-0002-7691-6635
- IdRef : 168071983
Bénédicte Stengel
- Fonction : Auteur
Christian Jacquelinet
- Fonction : Auteur
Philippe Aegerter
- Fonction : Auteur
Ziad Massy
- Fonction : Auteur
- PersonId : 1003368
- ORCID : 0000-0001-5771-5996
Antoine Vieillard-Baron
- Fonction : Auteur
- PersonId : 1335832
- ORCID : 0000-0002-4179-3583
- IdRef : 069545839
Stéphane Legriel
- Fonction : Auteur
Virginie Laurent
- Fonction : Auteur
Jean-Louis Teboul
- Fonction : Auteur
Anatole Virginie Tarazona
- Fonction : Auteur
Armand Mekontso-Dessap
- Fonction : Auteur
- PersonId : 1188370
- ORCID : 0000-0001-5961-5577
- IdRef : 130964603
Jean-Paul Mira
- Fonction : Auteur
- PersonId : 928244
Jean-Luc Diehl
- Fonction : Auteur
Romain Pirracchio
- Fonction : Auteur
Naike Bigé
- Fonction : Auteur
Claire Dupuis
- Fonction : Auteur
- PersonId : 1100666
- IdHAL : claire-dupuis
- ORCID : 0000-0002-3533-3097
Stéphane Gaudry
- Fonction : Auteur
Julien Maizel
- Fonction : Auteur
- PersonId : 926124
- ORCID : 0000-0001-5975-2635
- IdRef : 111324203
Bertrand Souweine
- Fonction : Auteur
Lara Zafrani
- Fonction : Auteur
Bruno Mégarbane
- Fonction : Auteur
- PersonId : 806590
- ORCID : 0000-0002-2522-2764
- IdRef : 07419190X
Alexandre Mebazaa
- Fonction : Auteur
Antoine Durbach
- Fonction : Auteur
Vincent Audard
- Fonction : Auteur
Eric Thervet
- Fonction : Auteur
Jean-Jacques Boffa
- Fonction : Auteur
Guillaume Hanouna
- Fonction : Auteur
Dimitri Titeca
- Fonction : Auteur
Carole Philiponnet
- Fonction : Auteur
Denis Glotz
- Fonction : Auteur
Résumé
Abstract Background Acute kidney injury (AKI) is frequent and associated with poor outcome in intensive care unit (ICU) patients. Besides the association with short- and long-term mortality, the increased risk of chronic kidney disease (CKD) has been recently highlighted in non-ICU patients. This study aims to describe the incidence and determinants of CKD after AKI and to develop a prediction score for CKD in ICU patients. Methods Prospective multicenter ( n = 17) observational study included 1200 ICU patients who suffered from AKI (defined by an AKIN stage ≥ 1) during their ICU stay and were discharged alive from ICU. Preexisting end-stage renal disease (ESRD) and immunosuppressant treatments are the main exclusion criteria. Patients will be monitored by a nephrologist at day 90 and every year for 3 years. The main outcome is the occurrence of CKD defined by a creatinine-based estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m 2 or renal replacement therapy for ESRD in patients whose eGFR will be normalized (≥ 60 mL/min/1.73 m 2 ) at day 90. Secondary outcomes include albuminuria changes, eGFR decline slope and ESRD risk in patients with preexisting CKD, cardiovascular and thromboembolic events and health-related quality of life. Discussion This is the first study prospectively investigating kidney function evolution in ICU patients who suffered from AKI. Albuminuria and eGFR monitoring will allow to identify ICU patients at risk of CKD who may benefit from close surveillance after recovering from AKI. Major patient and AKI-related determinants will be tested to develop a prediction score for CKD in this population. Trial registration ClinicalTrials.gov, NCT03282409. Registered on September 14, 2017
Domaines
Toxicologie Maladies émergentes Pneumologie et système respiratoire Maladies infectieuses Cardiologie et système cardiovasculaireFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study
|
Résumé |
en
Abstract Background Acute kidney injury (AKI) is frequent and associated with poor outcome in intensive care unit (ICU) patients. Besides the association with short- and long-term mortality, the increased risk of chronic kidney disease (CKD) has been recently highlighted in non-ICU patients. This study aims to describe the incidence and determinants of CKD after AKI and to develop a prediction score for CKD in ICU patients. Methods Prospective multicenter ( n = 17) observational study included 1200 ICU patients who suffered from AKI (defined by an AKIN stage ≥ 1) during their ICU stay and were discharged alive from ICU. Preexisting end-stage renal disease (ESRD) and immunosuppressant treatments are the main exclusion criteria. Patients will be monitored by a nephrologist at day 90 and every year for 3 years. The main outcome is the occurrence of CKD defined by a creatinine-based estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m 2 or renal replacement therapy for ESRD in patients whose eGFR will be normalized (≥ 60 mL/min/1.73 m 2 ) at day 90. Secondary outcomes include albuminuria changes, eGFR decline slope and ESRD risk in patients with preexisting CKD, cardiovascular and thromboembolic events and health-related quality of life. Discussion This is the first study prospectively investigating kidney function evolution in ICU patients who suffered from AKI. Albuminuria and eGFR monitoring will allow to identify ICU patients at risk of CKD who may benefit from close surveillance after recovering from AKI. Major patient and AKI-related determinants will be tested to develop a prediction score for CKD in this population. Trial registration ClinicalTrials.gov, NCT03282409. Registered on September 14, 2017
|
Auteur(s) |
Guillaume Geri
, Bénédicte Stengel
, Christian Jacquelinet
, Philippe Aegerter
, Ziad Massy
, Antoine Vieillard-Baron
, Stéphane Legriel
, Virginie Laurent
, Jean-Louis Teboul
, Anatole Virginie Tarazona
, Armand Mekontso-Dessap
, Jean-Paul Mira
, Jean-Luc Diehl
, Romain Pirracchio
, Naike Bigé
, Claire Dupuis
, Stéphane Gaudry
, Julien Maizel
, Bertrand Souweine
, Lara Zafrani
, Bruno Mégarbane
1
, Alexandre Mebazaa
, Antoine Durbach
, Vincent Audard
, Eric Thervet
, Jean-Jacques Boffa
, Guillaume Hanouna
, Dimitri Titeca
, Carole Philiponnet
, Denis Glotz
1
OPTeN (UMR_S 1144 / U1144) -
Optimisation thérapeutique en Neuropsychopharmacologie
( 1004834 )
- Faculté de Pharmacie Paris Descartes
4 avenue de l'Observatoire
75270 Paris Cedex 6
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2018-12
|
Volume |
8
|
Numéro |
1
|
Page/Identifiant |
77
|
Domaine(s) |
|
DOI | 10.1186/s13613-018-0421-7 |
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