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Pré-Publication, Document De Travail Année : 2022

An fMRI-based brain marker predicts individual differences in delay discounting

Résumé

Individual differences in impatience—how much we discount future compared to immediate rewards—are associated with general life outcomes and related to substance use, psychiatric diseases, and obesity. Here, we use machine-learning on fMRI activity during an intertemporal choice task to develop a brain marker of individual differences in delay discounting. Study 1 (N=110) was used as a training and cross-validation set, resulting in significant prediction accuracy ( r = 0.49) and suggesting an interplay between brain regions associated with affect, value, and cognitive control. The validity of the brain marker was replicated in an independent data set (Study 2, N=145, r = 0.45). In both studies, responses of the marker significantly differed between overweight and lean individuals. This pattern is a first step towards a generalizable neuromarker of delay discounting and a potentially transdiagnostic phenotype, which can be used as a brain-based target measure in future studies.

Domaines

Neurosciences
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Dates et versions

hal-03857823 , version 1 (17-11-2022)

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Citer

Leonie Koban, Sangil Lee, Daniela S Schelski, Marie-Christine Simon, Caryn Lerman, et al.. An fMRI-based brain marker predicts individual differences in delay discounting. 2022. ⟨hal-03857823⟩
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