Argon Pharmacokinetics: A Solubility Measurement Technique
Résumé
Schematic of the system. 2 Abstract 250 word max The Noble gas argon has demonstrated biological activity that may prove useful as a medical intervention. Pharmacokinetics (PK), the disposition of the drug molecule in the body through time, is fundamental necessary knowledge to drug discovery, development and even postmarketing. The fundamental measurement to perform in pharmacokinetic studies is blood concentration of the molecule (and its metabolites) of interest. While a physiologically based model of argon PK has appeared in the literature, no experimental data has been published. Thus, argon pharmaceutical development requires measurement of argon solubility in blood. This paper reports on the development of a technique based on mass spectrometry for measuring argon solubility in liquids, including blood, to be further employed in pharmacokinetics testing of argon. Based on a prototype, results are reported from sensitivity experiments using ambient air, water and rabbit blood. The key takeaway is that the system was sensitive to argon during all of the testing. We believe the technique and prototype of the quadrupole mass spectrometer gas analyzer will be capable of inferring argon pharmacokinetics through the analysis of blood samples.
Domaines
Chimie analytique
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