Article Dans Une Revue PLoS ONE Année : 2022

Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant

Résumé

Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena .

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hal-03854211 , version 1 (16-11-2022)

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Miao Tian, Kazufumi Mochizuki, Josef Loidl. Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant. PLoS ONE, 2022, 17 (2), pp.e0263691. ⟨10.1371/journal.pone.0263691⟩. ⟨hal-03854211⟩
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