A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity - Archive ouverte HAL
Article Dans Une Revue Journal of Medicinal Chemistry Année : 2012

A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity

Résumé

A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.

Dates et versions

hal-03853383 , version 1 (15-11-2022)

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Citer

Yi Xia, Menghua Wang, Olivier Demaria, Jingjie Tang, Palma Rocchi, et al.. A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity. Journal of Medicinal Chemistry, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩. ⟨hal-03853383⟩
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