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Article Dans Une Revue British Journal of Clinical Pharmacology Année : 2022

Adverse reactions with levamisole vary according to its indications and misuse: A systematic pharmacovigilance study

Résumé

Levamisole was initially prescribed for the treatment of intestinal worms. Because of immunomodulatory properties, levamisole has been used in inflammatory pathologies and in cancers in association with 5-fluorouracil. Levamisole is misused as a cocaine adulterant. Post-marketing reports have implicated levamisole in the occurrence of adverse drug reactions (ADRs) and its use is now limited in Europe and North America. In contrast, all other parts of the World continue to use single-dose levamisole as an anthelmintic. The aim of this study was to identify ADRs reported after levamisole exposure in VigiBase, the World Health Organisation's pharmacovigilance database, and analyse their frequency compared to other drugs and according to levamisole type of use.
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hal-03853323 , version 1 (15-11-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Jérémy T Campillo, Céline Eiden, Michel Boussinesq, Sébastien Pion, Jean-Luc Faillie, et al.. Adverse reactions with levamisole vary according to its indications and misuse: A systematic pharmacovigilance study. British Journal of Clinical Pharmacology, 2022, 88 (3), pp.1094-1106. ⟨10.1111/bcp.15037⟩. ⟨hal-03853323⟩
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