The Cognitive Interview for Suspects (CIS) is a recently designed information-gathering style interview method for interviewing suspects of crimes. Some components of this method (i.e., Mental context reinstatement, Report-everything inquiries) should make it possible to collect a large quantity of correct information, and to limit the misinformation-inducing impact of leading questions. However, certain other components (i.e., Reverse order, Challenge stages) are designed to increase cognitive load among interviewees, and might therefore lead to false confessions in innocent suspects. Using a protocol designed to provoke false confessions in innocent mock-suspects, the CIS was compared with another Information-Gathering interview method (IGM) and an Accusatory Interview (AI) on these different aspects. Results showed a benefit of the CIS in terms of information gathering and misinformation effects, compared to the two other interviews. Moreover, it did not increase the risk of false confessions. These conclusions are of interest for field investigators, who could use this method with suspects in real cases.