Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2021

Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis

Shai Adar-Levor
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Shani Gal-Oz
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Yarden Jahn
  • Fonction : Auteur
Nadine Peyrieras
  • Fonction : Auteur
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Assaf Zaritsky
Ramon Birnbaum
Natalie Elia

Résumé

Significance In this work, we show that the last step of cytokinesis, termed abscission, is delayed in early zebrafish embryos. As a result, sibling cells remain connected to one another by a thin membrane bridge for several cycles, forming clusters of interconnected cells. Bridge severing (i.e., abscission) commences at the 10th cell cycle when embryos enter the midblastula transition switch, in which embryonic cells become individualized and exhibit the characteristics of mature cells. Cells connected by intercellular bridges shared similar cellular behaviors, such as transcription onset and cell shape. Our data suggest that cell–cell connectivity is maintained in early embryos through persistent bridge connections that allow cells to coordinate their behavior during embryonic development.

Dates et versions

hal-03844291 , version 1 (08-11-2022)

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Citer

Shai Adar-Levor, Dikla Nachmias, Shani Gal-Oz, Yarden Jahn, Nadine Peyrieras, et al.. Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (15), ⟨10.1073/pnas.2021210118⟩. ⟨hal-03844291⟩
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