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Article Dans Une Revue Journal of Synchrotron Radiation Année : 2022

Evaluation of imaging setups for quantitative phase contrast nanoCT of mineralized biomaterials

Résumé

X-ray nano-tomography with phase contrast (nanoCT) using synchrotron radiation is a powerful tool to non-destructively investigate 3D material properties at the nanoscale. In large bone lesions, such as severe bone fractures, bone cancer or other diseases, bone grafts substituting the lost bone might be necessary. Such grafts can be of biological origin or be composed of a synthetic bone substitute. The long-term functioning of artificial bone substitutes depends on many factors. Synchrotron nanoCT imaging has great potential to contribute to further the understanding of integration of implants into bone tissue by imaging the spatial interaction between bone tissue and implant, and by accessing the interface between implant material and bone tissue. With this aim, a methodology for evaluating the image quality is presented for in-line phase contrast nanoCT images of bone scaffold samples. A PMMA-embedded tricalcium phosphate scaffold was used with both a closed and an open porosity structure and bone ingrowths as a representative system of three known materials. Parameters such as spatial resolution and signal-to-noise ratio were extracted and used to explore and quantitatively compare the effects of implementation choices in the imaging setup, such as camera technology and imaging energy, on the resulting image quality. Increasing the X-ray energy from 17.5 keV to 29.6 keV leads to a notable improvement in image quality regardless of the camera technology used, with the two tested camera setups performing at a comparable level when the recorded intensity was kept constant.
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Origine : Publication financée par une institution

Dates et versions

hal-03839386 , version 1 (04-11-2022)

Identifiants

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Jussi-Petteri Suuronen, Bernhard Hesse, Max Langer, Marc Bohner, Julie Villanova. Evaluation of imaging setups for quantitative phase contrast nanoCT of mineralized biomaterials. Journal of Synchrotron Radiation, 2022, 29 (3), pp.843-852. ⟨10.1107/S1600577522003137⟩. ⟨hal-03839386⟩
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