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Journal Articles Physical Review Letters Year : 2022

Stoichiometry Controls the Dynamics of Liquid Condensates of Associative Proteins

Abstract

Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such “bond-network” condensates comprised of two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative partners following a bond break. This microscopic slow-down strongly affects the bulk diffusivity, viscosity and mixing, which provides a means to experimentally test our predictions.
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hal-03838324 , version 1 (21-09-2023)

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Pierre Ronceray, Yaojun Zhang, Xichong Liu, Ned Wingreen. Stoichiometry Controls the Dynamics of Liquid Condensates of Associative Proteins. Physical Review Letters, 2022, 128 (3), pp.038102. ⟨10.1103/PhysRevLett.128.038102⟩. ⟨hal-03838324⟩
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