Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of diabetes research Année : 2017

Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries

Olivia Lenoir
François Gaillard
  • Fonction : Auteur
Hélène Lazareth
Blaise Robin
  • Fonction : Auteur
Pierre-Louis Tharaux

Résumé

Objective. Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy. The goal of this study was to assess the role of HO-1 in the development of microvascular lesions within glomeruli during diabetes mellitus using a mouse model with specific alteration of the Hmox1 gene. Approach and Results. The effects of Hmox1 haploinsufficiency were studied as a means of assessing the intrinsic contribution of HO-1 in the development of renal microvascular lesions during diabetes. Renal function and histology were analyzed 10 weeks after diabetes induction with streptozotocin. Diabetic Hmox1 +/− mice showed higher levels of albuminuria and blood urea compared to their wild-type diabetic littermates. More severe glomerular microvascular lesions were also observed in the diabetic Hmox1 +/− mice. This was associated with a renal increase in the expression of the oxidative stress marker, nitrotyrosine. Conclusions. Genetic Hmox1 partial deficiency is sufficient to sensitize mice to the development of diabetic glomerular microvascular lesions. HO-1 exerts antioxidant effects in the kidney during diabetes mellitus. These have protective effects on the development of glomerular endothelial injury.
Fichier principal
Vignette du fichier
9603924.pdf (7.2 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03832394 , version 1 (22-12-2023)

Identifiants

Citer

Olivia Lenoir, François Gaillard, Hélène Lazareth, Blaise Robin, Pierre-Louis Tharaux. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. Journal of diabetes research, 2017, 2017, pp.1-7. ⟨10.1155/2017/9603924⟩. ⟨hal-03832394⟩

Collections

UP-SANTE
6 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More