Synthesis and Spectroscopic Characterization of Novel Thiourea-Bearing Photoactivatable NADPH Mimics Targeting NO Synthases - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2022

Synthesis and Spectroscopic Characterization of Novel Thiourea-Bearing Photoactivatable NADPH Mimics Targeting NO Synthases

Résumé

Abstract A new set of photoactivatable NADPH mimics bearing a thiourea linkage between a diarylbutadiene and an adenosine moiety functionalized by O-carboxymethyl groups has been designed and synthesized in a convergent strategy. These compounds display absorption and fluorescence emission maxima in DMSO (λmax,abs = 390 nm and λmax,em = 460 nm, respectively) consistent with the previously described analogues, with good fluorescence quantum yields (ΦF = 0.35–0.36), as well as two-photon absorption (σ2 = 10.1 GM at λmax,exc = 780 nm). These molecules could be useful photosensitive tools for biological studies, especially for cellular studies of nitric oxide synthases.
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hal-03831291 , version 1 (26-10-2022)

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Clément Polese, Eric Deprez, Patrick Tauc, Nicolas Bogliotti, Juan Xie. Synthesis and Spectroscopic Characterization of Novel Thiourea-Bearing Photoactivatable NADPH Mimics Targeting NO Synthases. Synthesis: Journal of Synthetic Organic Chemistry, 2022, 54 (10), pp.2447-2456. ⟨10.1055/s-0041-1737374⟩. ⟨hal-03831291⟩
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