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Article Dans Une Revue Annals of the Rheumatic Diseases Année : 2017

The EuroMyositis registry: an international collaborative tool to facilitate myositis research

James Lilleker
Jiri Vencovsky
Guochun Wang
  • Fonction : Auteur
Louise Pyndt Diederichsen
Jens Schmidt
  • Fonction : Auteur
Paula Oakley
  • Fonction : Auteur
Maria Giovanna Danieli
Katalin Danko
  • Fonction : Auteur
Nguyen Thi Phuong Thuy
  • Fonction : Auteur
Monica Vazquez-del Mercado
  • Fonction : Auteur
Helena Andersson
  • Fonction : Auteur
Jan Debleecker
  • Fonction : Auteur
Britta Maurer
  • Fonction : Auteur
Liza Mccann
  • Fonction : Auteur
Nicolo Pipitone
  • Fonction : Auteur
Neil Mchugh
  • Fonction : Auteur
Zoe Betteridge
  • Fonction : Auteur
Paul New
  • Fonction : Auteur
Robert Cooper
  • Fonction : Auteur
William Ollier
  • Fonction : Auteur
Janine Lamb
  • Fonction : Auteur
Niels Steen Krogh
  • Fonction : Auteur
Ingrid Lundberg
  • Fonction : Auteur
Hector Chinoy
  • Fonction : Auteur

Résumé

Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001). Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001). ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. Conclusion This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
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hal-03831192 , version 1 (15-11-2022)

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James Lilleker, Jiri Vencovsky, Guochun Wang, Lucy Wedderburn, Louise Pyndt Diederichsen, et al.. The EuroMyositis registry: an international collaborative tool to facilitate myositis research. Annals of the Rheumatic Diseases, 2017, 77 (1), pp.30-39. ⟨10.1136/annrheumdis-2017-211868⟩. ⟨hal-03831192⟩
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