Aggregation of cyclodextrins: An explanation of the abnormal solubility ofβ-cyclodextrin
Résumé
a-,ß- and ?-Cyclodextrins have been shown to exist as aggregates in solution bound together by a network of hydrogen bonds. Removal of this network by ionisation of the hydroxyl groups leads to a greatly increased solubility and removal of aggregation. The presence of aggregates in solution of structure breaking solutes in which the solubility ofß-cyclodextrin is greatly enhanced, leads to a proposal that the abnormally low solubility ofß-CD may be explained by the presence of aggregates and the unfavourable interaction of these aggregates with the hydrogen bonded structure of water.