Temperature effect on dislocation loop density and radiation-induced segregation (RIS) phenomena are investigated on an ion irradiated 15Cr-46Fe-17Mn-22Ni (at.%) multi-principal element alloy (MPEA) over a wide range of temperatures. From 95K to 623K, loop densities are temperature independent and close to ~5.0×1022 m-3. Above 623K, loop densities decrease until ~1.05×1021 m-3 at 823K. This tendency is the same as in the conventional ternary Fe-Cr-Ni alloys. Besides, Ni enrichment and Cr, Fe, Mn depletion on loops are observed at 823K by scanning transmission electron microscopy coupled to energy dispersive X-ray spectroscopy and atom probe tomography with comparable RIS amplitude. This solute redistribution is explained by an inverse Kirkendall (IK) mechanism. In contrast, no obvious chemical segregation/depletion phenomena are detected at 298K, which reveals the temperature dependence of the IK effect. This comprehensive study of loop behavior as a function of temperature gives a better understanding of CrFeMnNi MPEAs under irradiation.