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Article Dans Une Revue Archives de pediatrie : organe officiel de la Societe francaise de pediatrie Année : 2012

[Neuromyelitis optica in children. Two case reports].

Résumé

Devic neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associating acute transverse myelitis and optic neuritis. This is a different disease from multiple sclerosis for which the presence of the NMO antibody directed against aquaporin 4 is a specific marker. Brain damage on MRI does not exclude the diagnosis; the location is superposable in the brain zones rich in aquaporin 4 channels. We report 2 cases of NMO with anti-aquaporin 4. One patient was not symptomatic of brain damage. In this patient, the affinity of anti-NMO for aquaporin 4, studied by flow cytometry, was particularly high. Both patients were treated with immunosuppressive agents (rituximab) due to the failure of or dependence on high-dose corticosteroids.

Dates et versions

hal-03828894 , version 1 (25-10-2022)

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Citer

B. Tosello, C. Halbert, J. Mancini, B. Chabrol, J. Boucraut, et al.. [Neuromyelitis optica in children. Two case reports].. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2012, 19 (8), pp.827--831. ⟨10.1016/j.arcped.2012.05.019⟩. ⟨hal-03828894⟩
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