A facile one-pot synthesis of new poly functionalized pyrrolotriazoles via a regioselective multicomponent cyclisation and Suzuki–Miyaura coupling reactions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Catalysts Année : 2022

A facile one-pot synthesis of new poly functionalized pyrrolotriazoles via a regioselective multicomponent cyclisation and Suzuki–Miyaura coupling reactions

Résumé

The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported. The series were generated using a “one-pot” MCR, leading to a single regioisomer of the attempted heteroaromatic skeleton in good yields. Next, the functionalization of C-5 and C-6 positions was investigated. (Het)aryl groups were introduced at the C-5 and C-6 positions of the pyrrolo[2,3-d][1,2,3]triazoles using regioselective electrophilic brominations followed by Suzuki–Miyaura cross coupling reactions. Palladium-catalyzed cross-coupling conditions were optimized and a representative library of various boronic acids was employed to establish the scope and limitations of the method

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Matériaux
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hal-03820676 , version 1 (19-10-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Simon Garnier, Kévin Brugemann, Agnieszka Zak, Johnny Vercouillie, Marie Potier-Cartereau, et al.. A facile one-pot synthesis of new poly functionalized pyrrolotriazoles via a regioselective multicomponent cyclisation and Suzuki–Miyaura coupling reactions. Catalysts, 2022, 12 (8), pp.828. ⟨10.3390/catal12080828⟩. ⟨hal-03820676⟩
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