Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Materials Année : 2022

Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review

Résumé

Background: The toxicological risk of Co-Cr dental alloys is actually a sensitive subject with the European regulatory changes, namely regulation (EU) 2017/745 and annex VI to the CLP regulation (EC) 1972/2008. Objectives: The objective of this review is to conduct a rigorous analysis of the cytocompatibility of cobalt–chromium (Co-Cr) dental alloys. Considering various parameters such as cytotoxicity, type IV hypersensitivity reaction, sensitization, and irritation, we investigated evidence of toxicity of Co-Cr in human dental applications. Data sources: Specific search strategies were performed in three electronic databases, namely Medline, Embase, and Web of Science, using a main restriction in the search regarding the publication date (1995–2022). Study selection: Out of a total of 836 articles, only 21 studies were selected and analyzed according to PRISMA methodology. Results: Among them, 10 in vitro studies using human samples and 11 in vivo studies on human patients were distinguished. Most of the in vitro studies confirmed that Co-Cr alloys have a good cytocompatibility compared to Ni alloys. Regarding the in vivo studies, it appeared that Co-Cr could rarely cause sensitization, irritation, and allergic reactions. Reactions were mainly observed for people allergic to Co or Cr. Nevertheless, titanium-based materials showed better results. Conclusions: This study proposes a new state of the art on Co-Cr dental alloys and will thus be very useful for carrying out additional studies. Relevance: This review will help practitioners in their daily clinical choice
Fichier principal
Vignette du fichier
materials-15-05801_MLB.pdf (501.99 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03815561 , version 1 (14-10-2022)

Identifiants

Citer

Brigitte Grosgogeat, Alina Vaicelyte, Rémy Gauthier, Christine Janssen, Marc Le Borgne. Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review. Materials, 2022, 15 (17), pp.5801. ⟨10.3390/ma15175801⟩. ⟨hal-03815561⟩
45 Consultations
128 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More