Age-dependent changes in the mechanical properties of tail tendons in TGF-β inducible early gene-1 knockout mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Applied Physiology Année : 2006

Age-dependent changes in the mechanical properties of tail tendons in TGF-β inducible early gene-1 knockout mice

Résumé

The purpose of this study is to investigate age-dependent changes in the architecture and mechanical properties of tendon in TGF-␤ inducible early gene-1 (TIEG) knockout mice. Wild-type and TIEG knockout mice, aged 1, 2, and 15 mo, were used. The mechanical properties of tail tendons isolated from these mice were determined using uniaxial tensile ramp (0.05 mm/s) and relaxation (5 mm/s) tests, with a strain of 10%. Mechanical parameters (Young's modulus from the ramp test; fast and static stresses from the relaxation test) were measured and recorded. The structure of the tail tendon fascicle was characterized by transmission electron microscopy. The results of the mechanical testing revealed no significant difference between the knockout and wild-type groups at 1 or 15 mo of age. However, the fascicles of the knockout mice at 3 mo of age exhibited decreased fast and static stresses compared with those of the wild-type mice. Electron microscopy revealed an increase in fibril size in the knockout mouse tendons relative to wild-type controls at 1 and 3 mo of age. These data indicate an important role for TIEG in tendon microarchitecture and strength in adult mice. tensile strength; tendon fibrils 1420 AGE-DEPENDENT CHANGES IN TAIL TENDONS IN TIEG MICE
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Dates et versions

hal-03812674 , version 1 (12-10-2022)

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Sabine F Bensamoun, Tetsu Tsubone, Malayannan Subramaniam, John R Hawse, Emir Boumediene, et al.. Age-dependent changes in the mechanical properties of tail tendons in TGF-β inducible early gene-1 knockout mice. Journal of Applied Physiology, 2006, 101, pp.1419 - 1424. ⟨10.1152/japplphysiol.00800.2005⟩. ⟨hal-03812674⟩
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