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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2022

Fungal gasdermin-like proteins are controlled by proteolytic cleavage

Witold Dyrka
Elizabeth Turcotte
Alexandra Granger-Farbos
  • Fonction : Auteur
Léa Ibarlosa
Russell Vance
Sven Saupe

Résumé

Significance The recent discovery of gasdermin-like proteins in fungi have brought to light that this family of pore-forming proteins controls cell death in two of the major eukaryotic kingdoms, fungi and mammals. Yet the regulation of cytotoxicity of the fungal gasdermins and their molecular pathways remain uncharacterized. Here, we describe the regulation through proteolytic cleavage of the fungal gasdermin HET-Q1 and uncover that a majority of fungal gasdermins are genomically clustered with protease-encoding genes. Some of these genes encode proteins with caspase-related domains and/or are members of a family of immune receptors in mammals and plants. Overall, this work contributes toward our understanding of the evolution of gasdermin-dependent cell death, enlightening multiple evolutionary parallels between signaling pathways in mammals and fungi.

Dates et versions

hal-03812364 , version 1 (12-10-2022)

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Citer

Corinne Clavé, Witold Dyrka, Elizabeth Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, et al.. Fungal gasdermin-like proteins are controlled by proteolytic cleavage. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (7), ⟨10.1073/pnas.2109418119⟩. ⟨hal-03812364⟩

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