Phosphorus dendron nanomicelles as a platform for combination anti-inflammatory and antioxidative therapy of acute lung injury

Development of novel nanomedicines to inhibit pro-inflammatory cytokine expression and reactive oxygen species (ROS) generation for anti-inflammatory therapy of acute lung injury (ALI) remains challenging. Here, we present a new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with antioxidant drug curcumin (Cur).

Mots clés

Phosphorus dendrons Nanomicelles Curcumin Alveolar macrophages NF-κB Acute lung injury

Domaines

Biochimie, Biologie Moléculaire

Fichier principal

Li, Phosphorus dendron nanomicelles, 2022.pdf (2.95 Mo)

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https://hal.science/hal-03807996

Soumis le : lundi 10 octobre 2022-11:53:01

Dernière modification le : jeudi 18 juillet 2024-10:51:28

Archivage à long terme le : mercredi 11 janvier 2023-18:56:04

Dates et versions

hal-03807996 , version 1 (10-10-2022)

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Paternité

Identifiants

HAL Id : hal-03807996 , version 1
DOI : 10.7150/thno.70701

Citer

Jin Li, Liang Chen, Changsheng Li, Yu Fan, Mengsi Zhan, et al.. Phosphorus dendron nanomicelles as a platform for combination anti-inflammatory and antioxidative therapy of acute lung injury. Theranostics, 2022, 12 (7), pp.3407-3419. ⟨10.7150/thno.70701⟩. ⟨hal-03807996⟩

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