New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole - Archive ouverte HAL
Article Dans Une Revue Antibiotics Année : 2022

New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole

Rodolphe Auger
  • Fonction : Auteur
Michaël Bosco

Résumé

New inhibitors of the bacterial transferase MraY from Aquifex aeolicus (MraYAA), based on the aminoribosyl uridine central core of known natural MraY inhibitors, have been designed to generate interaction of their oxadiazole linker with the key amino acids (H324 or H325) of the enzyme active site, as observed for the highly potent inhibitors carbacaprazamycin, muraymycin D2 and tunicamycin. A panel of ten compounds was synthetized notably thanks to a robust microwave-activated one-step sequence for the synthesis of the oxadiazole ring that involved the O-acylation of an amidoxime and subsequent cyclization. The synthetized compounds, with various hydrophobic substituents on the oxadiazole ring, were tested against the MraYAA transferase activity. Although with poor antibacterial activity, nine out of the ten compounds revealed the inhibition of the MraYAA activity in the range of 0.8 µM to 27.5 µM.

Domaines

Chimie
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Dates et versions

hal-03805942 , version 1 (17-11-2022)

Identifiants

Citer

Hongwei Wan, Raja Ben Othman, Laurent Le Corre, Mélanie Poinsot, Martin Oliver, et al.. New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole. Antibiotics, 2022, 11 (9), pp.1189. ⟨10.3390/antibiotics11091189⟩. ⟨hal-03805942⟩
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