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Article Dans Une Revue Current Opinion in Endocrine and Metabolic Research Année : 2022

The glucocorticoid footprint on the memory engram

Freddy Jeanneteau
Laurence Coutellier
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Résumé

The complexity of the classical inverted U-shaped relationship between cortisol levels and responses transposable to stress reactivity has led to an incomplete understanding of the mechanisms enabling healthy and toxic effects of stress on brain and behavior. A clearer, more detailed, picture of those relationships can be obtained by integrating cortisol effects on large-scale brain networks, in particular, by focusing on neural network configurations from the perspective of inhibition and excitation. A unifying view of Semon and Hebb's theories of cellular memory links the biophysical and metabolic changes in neuronal ensembles to the strengthening of collective synapses. In that sense, the neuronal capacity to record, store, and retrieve information directly relates to the adaptive capacity of its connectivity and metabolic reserves. Here, we use task-activated cell ensembles or simply engram cells as an example to demonstrate that the adaptive behavioral responses to stress result from collective synapse strength within and across networks of interneurons and excitatory ones.
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Dates et versions

hal-03800497 , version 1 (18-10-2022)

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Freddy Jeanneteau, Laurence Coutellier. The glucocorticoid footprint on the memory engram. Current Opinion in Endocrine and Metabolic Research, 2022, 25, ⟨10.1016/j.coemr.2022.100378⟩. ⟨hal-03800497⟩
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