A new versatile MR‑guided high‑intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2022

A new versatile MR‑guided high‑intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors

Résumé

Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce a new modular MRgHIFU device that allows the ultrasound transducer to be positioned precisely and interactively over the body part to be treated. A flexible, MR-compatible supporting structure allows free positioning of the transducer under MRI/optical fusion imaging guidance. The same structure can be rigidified using pneumatic depression, holding the transducer rigidly in place. Targeting accuracy was first evaluated in vitro. The average targeting error of the complete process was found to be equal to 5.4 ± 2.2 mm in terms of focus position, and 4.7° ± 2° in terms of transducer orientation. First-in-man feasibility is demonstrated on a patient suffering from important, uncontrolled pain from a bone metastasis located in the forearm. The 81 × 47 × 34 mm3 lesion was successfully treated using five successive positions of the transducer, under real-time monitoring by MR Thermometry. Significant pain palliation was observed 3 days after the intervention. The system described and characterized in this study is a particularly interesting modular, low-cost MRgHIFU device for musculoskeletal tumor therapy.
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Origine : Publication financée par une institution

Dates et versions

hal-03797770 , version 1 (08-11-2022)

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Paolo Cabras, Pierre Auloge, Fabrice Bing, Pramod Prabhakar Rao, Stéphanie Hoarau, et al.. A new versatile MR‑guided high‑intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors. Scientific Reports, 2022, 12, ⟨10.1038/s41598-022-13213-1⟩. ⟨hal-03797770⟩
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