Dual Host-Intracellular Parasite Transcriptome of Enucleated Cells Hosting Leishmania amazonensis : Control of Half-Life of Host Cell Transcripts by the Parasite - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Infection and Immunity Année : 2020

Dual Host-Intracellular Parasite Transcriptome of Enucleated Cells Hosting Leishmania amazonensis : Control of Half-Life of Host Cell Transcripts by the Parasite

Cristina Orikaza
Carina Pessoa
  • Fonction : Auteur
Fernanda Paladino
  • Fonction : Auteur
Pilar Florentino
  • Fonction : Auteur
Clara Barbiéri
  • Fonction : Auteur
Hiro Goto
Eduardo Milton Ramos-Sanchez
  • Fonction : Auteur
José Franco da Silveira
  • Fonction : Auteur
Renato Mortara
Fernando Real

Résumé

Enucleated cells or cytoplasts (cells whose nucleus is removed in vitro ) represent an unexplored biological model for intracellular infection studies due to the abrupt interruption of nuclear processing and new RNA synthesis by the host cell in response to pathogen entry. Using enucleated fibroblasts hosting the protozoan parasite Leishmania amazonensis , we demonstrate that parasite multiplication and biogenesis of large parasitophorous vacuoles in which parasites multiply are independent of the host cell nucleus.
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Dates et versions

hal-03796638 , version 1 (04-10-2022)

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Cristina Orikaza, Carina Pessoa, Fernanda Paladino, Pilar Florentino, Clara Barbiéri, et al.. Dual Host-Intracellular Parasite Transcriptome of Enucleated Cells Hosting Leishmania amazonensis : Control of Half-Life of Host Cell Transcripts by the Parasite. Infection and Immunity, 2020, 88 (11), ⟨10.1128/IAI.00261-20⟩. ⟨hal-03796638⟩
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