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Article Dans Une Revue Chemistry Proceedings Année : 2022

Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

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In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA. The antioxidant effects of substituted 2-aminopyridine δ-lactone derivatives were evaluated through DPPH assay and revealed a great antioxidant capacity. The antifungal and antibacterial activities were investigated by disc diffusion method against clinical Gram-negative bacteria and against clinical fungi. The study shows moderate to very good antibacterial and antifungal activities for the new substituted 2-aminopyridine δ-lactone derivatives.
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hal-03790910 , version 1 (28-09-2022)

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Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar. Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties. Chemistry Proceedings, 2022, This article belongs to the Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 6 (1), pp.9. ⟨10.3390/ecsoc-25-11709⟩. ⟨hal-03790910⟩
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