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Article Dans Une Revue World Allergy Organization Journal Année : 2022

Allergic manifestations of inborn errors of immunity and their impact on the diagnosis: A worldwide study

1 ASU - Ain Shams University
2 Clinica de Alergía Pediatríca S.C. Dr José G Huerta López
3 Hospital Nacional Edgardo Rebagliati Martins
4 Al-Sabah Hospital
5 Hamad Medical Corporation [Doha, Qatar]
6 Institute of Biomedical Sciences - Department of Immunology [Sao Paulo]
7 Royal Alexandra Children's Hospital
8 University of Cape Town Medical school
9 University of Khartoum
10 INP - Instituto Nacional de Pediatria
11 CHUC - Coimbra Hospital and Universitary Centre [Coimbra, Portugal]
12 UTFPR - Universidade Tecnológica Federal do Paraná [Curitiba, Brasil] = Federal Technological University of Paraná [Curitiba, Brazil] = Université technologique fédérale du Paraná [Curitiba, Brésil]
13 CUMC - Columbia University Medical Center
14 Cairo University - Faculty of Medicine
15 NHGRI - National Human Genome Research Institute
16 Children's Hospital of Wisconsin
17 TMDU - Tokyo Medical and Dental University [Japan]
18 Hotel-Dieu de France Hospital
19 Institut Pasteur d'Algérie
20 University Hospital Motol [Prague]
21 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
22 Bone Marrow Transplantation Center Tunis
23 Ud'A - Università degli studi "G. d'Annunzio" Chieti-Pescara [Chieti-Pescara]
24 University of Naples Federico II = Università degli studi di Napoli Federico II
25 Department of Post Medical Education, Aga Khan University Hospital, Karachi, Pakistan
26 University of Rome la Sapienza
27 Post Graduate Institute of Child Health
28 TUMS - Tehran University of Medical Sciences
29 Universal Scientific Education and Research Network (USERN)
30 PGIMER - Post Graduate Institute of Medical Education and Research [Chandigarh, India]
31 HTA - Hospital Tunku Azizah
32 GICH - Jafar Ibn Auf Pediatric Hospital
33 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
34 IDESP - Institut Desbrest de santé publique
35 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
36 SNMAPE - Shupyk National Medical Academy of Postgraduate Education [Kiev]
37 CHOP - Children’s Hospital of Philadelphia
Waleed Al-Herz
  • Fonction : Auteur

Résumé

Background: Allergies have long been observed in Inborn Errors of Immunity (IEI) and might even be the first presentation resulting in delayed diagnosis or misdiagnosis in some cases. However, data on the prevalence of allergic diseases among IEI patients are limited and contradictory. Objective: To provide a worldwide view of allergic diseases, across a broad spectrum of IEI, and their impact on the timely diagnosis of IEI. Methods: This is a worldwide study, conceived by the World Allergy Organization (WAO) Inborn Errors of Immunity Committee. A questionnaire was developed and pilot-tested and was sent via email to collect data from 61 immunology centers known to treat pediatric and/or adult IEI patients in 41 countries. In addition, a query was submitted to The United States Immunodeficiency Network (USIDNET) at its website. Results: Thirty centers in 23 countries caring for a total of 8450 IEI patients responded. The USIDNET dataset included 2332 patients. Data from responders showed that a median (IQR) of 16.3% (10-28.8%) of patients experienced allergic diseases during the course of their IEI as follows: 3.6% (1.3-11.3%) had bronchial asthma, 3.6% (1.9-9.1%) atopic dermatitis, 3.0% (1.0-7.8%)
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hal-03780636 , version 1 (19-09-2022)

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Zeinab El-Sayed, Dalia El-Ghoneimy, José Ortega-Martell, Nesrine Radwan, Juan Aldave, et al.. Allergic manifestations of inborn errors of immunity and their impact on the diagnosis: A worldwide study. World Allergy Organization Journal, 2022, 15 (6), pp.100657. ⟨10.1016/j.waojou.2022.100657⟩. ⟨hal-03780636⟩
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