Biophysical control of neural trajectories under disordered brain dynamics - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2022

Biophysical control of neural trajectories under disordered brain dynamics

Matthieu Sarazin
David Medernach
  • Fonction : Auteur
Jérémie Naudé
Bruno Delord

Résumé

Abstract Neural trajectories constitute propagating sequences of activity that are essential to cognitive representations. Understanding how neural trajectories overcome the disorganizing influence of neural noise in the awake state remains challenging. Theoretical and artificial network models have focused on optimizing the synaptic pathways underlying trajectory propagation. However, in a biophysical network with synaptic plasticity, solely altering synaptic connectivity induces a tight tradeoff between spurious trajectory interruptions and inductions by noise. Formal analysis predicts that separating the inhibitory fluctuations-driven spontaneous activity from the excitatory-driven trajectory propagation is key to reliable triggering and propagation. Amongst biophysical solutions, calcium-activated suprathreshold intrinsic conductances provided the best trajectory reliability by mitigating the reliance of propagation on connectivity. These mechanisms display parametric robustness and generalize to a variety of static and dynamic attractors with uni- and bidirectional propagation. Thus, we provide a unified framework for cognitive-associated neural trajectories robust to neural noise in the awake state.

Dates et versions

hal-03766500 , version 1 (01-09-2022)

Identifiants

Citer

Matthieu Sarazin, David Medernach, Jérémie Naudé, Bruno Delord. Biophysical control of neural trajectories under disordered brain dynamics. 2022. ⟨hal-03766500⟩
16 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More