Topological photonics provides an important platform for the development of photonic devices with robust disorder-immune light transport and controllable helicity. Mixing photons with excitons (or polaritons) gives rise to nontrivial polaritonic bands with chiral modes, allowing the manipulation of helical lasers in strongly coupled light-matter systems. In this work, helical polariton lasing from topological valleys of an organic anisotropic microcrystalline cavity based on tailored local nontrivial band geometry is demonstrated. This polariton laser emits light of different helicity along different angular directions. The significantly enhanced chiral characteristics are achieved by the nonlinear relaxation process. Helical topological polariton lasers may provide a perfect platform for the exploration of novel topological phenomena that involve light-matter interaction and the development of polariton-based spintronic devices.