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Pré-Publication, Document De Travail Année : 2022

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

Stéphanie Jacquet
Michelle Culbertson
  • Fonction : Auteur
Chi Zang
  • Fonction : Auteur
Adil El Filali
  • Fonction : Auteur
Clément de la Myre Mory
  • Fonction : Auteur
Jean-Baptiste Pons
  • Fonction : Auteur
Ondine Filippi-Codaccioni
  • Fonction : Auteur
M. Elise Lauterbur
  • Fonction : Auteur
Barthélémy Ngoubangoye
  • Fonction : Auteur
Jeanne Duhayer
  • Fonction : Auteur
Clément Verez
  • Fonction : Auteur
Chorong Park
  • Fonction : Auteur
Clara Dahoui
  • Fonction : Auteur
Clayton Carey
  • Fonction : Auteur
Greg Brennan
  • Fonction : Auteur
David Enard
  • Fonction : Auteur
Andrea Cimarelli
Stefan Rothenburg
  • Fonction : Auteur
Nels Elde
Dominique Pontier

Résumé

Abstract Several bat species act as asymptomatic reservoirs for many viruses that are instead highly pathogenic in other mammals. Here, we have characterized the functional diversification of the Protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive selection and has undergone repeated genomic duplications in bats, in contrast to all studied mammals that possess a single copy of the gene. Functional testing of the relationship between PKR and poxvirus antagonists revealed how an evolutionary conflict with ancient pathogenic poxviruses has shaped a specific bat host-virus interface. More importantly, we determined that duplicated PKRs of the Myotis species have undergone functional diversification allowing them to collectively escape from and enhance control of DNA and RNA viruses. These findings suggest that viral-driven adaptations in PKR contribute to modern virus-bat interactions and may account for bat specific immunity.

Dates et versions

hal-03761751 , version 1 (26-08-2022)

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Stéphanie Jacquet, Michelle Culbertson, Chi Zang, Adil El Filali, Clément de la Myre Mory, et al.. Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions. 2022. ⟨hal-03761751⟩
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