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Article Dans Une Revue Frontiers in Immunology Année : 2022

Extracellular Vesicles in Transplantation

Résumé

Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is now well documented that they can actively participate in the activation or regulation of immune system functions through different mechanisms, the most studied of which include protein-protein interactions and miRNA transfers. The functional diversity of EVsecreting cells makes EVs potential targets for immunotherapies through immune cellderived EV functions. They are also a potential source of biomarkers of graft rejection through donor cells or graft environment-derived EV content modification. This review focuses on preclinical studies that describe the role of EVs from different cell types in immune suppression and graft tolerance and on the search for biomarkers of rejection.
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Dates et versions

hal-03761569 , version 1 (26-08-2022)

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Nicolas Sailliet, Matti Ullah, Amandine Dupuy, Amanda K A Silva, Florence Gazeau, et al.. Extracellular Vesicles in Transplantation. Frontiers in Immunology, 2022, 13, pp.800018. ⟨10.3389/fimmu.2022.800018⟩. ⟨hal-03761569⟩
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