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Article Dans Une Revue European Journal of Public Health Année : 2019

Giving blood: providing treatment, providing knowledge

P Tiberghien
  • Fonction : Auteur
P Gallian
  • Fonction : Auteur
P Morel
  • Fonction : Auteur
J Chiaroni
S Gross
  • Fonction : Auteur
R Djoudi
  • Fonction : Auteur
J-C Pagès
  • Fonction : Auteur
F Toujas
  • Fonction : Auteur

Résumé

Abstract Background In France, 1,6 million donors contribute 3 million blood donations / year collected and tested by the French public transfusion service (Etablissement Français du Sang - EFS). At each donation, 2 ml plasma of are stored for 3 years for further testing if needed. In addition to providing life-saving blood products, blood donors may also provide knowledge through the sharing of their health data and bioresource collected at time of donation. Objective To describe how blood donors can provide knowledge in addition to blood products. Results Over the last 10 years, blood donors in France have enabled several studies performed by EFS in collaboration with research and reference laboratories as well as public health authorities. A linked assessment of Ab titers (+ clinical history) in donors having given blood before and after the 2009 H1N1 flu epidemic, as well as measles, rubella and hepatitis E virus seroprevalence studies (+ specific health questionnaires) have generated high value epidemiological data. Screening for arboviruses (such as Zika virus) and hepatitis A virus in donors during epidemics have increased knowledge of infectious spread and disease characteristics. Testing of plasma samples collected before variant Creutzfeldt-Jakob disease occurrence in two donors revealed the presence of circulating prion more than 1 year before diagnosis. A project to further take advantage of such a bio resource is underway. Upon occurrence and notification of a disease (or any pre-defined health event) in one of the 1,4 million repeat blood donors, all samples from prior donations would be gathered in a cohort of samples of all donors having notified an identical health event. Such cohorts would provide valuable samples to assess disease-specific biomarkers at pre-symptomatic phases. Conclusions Providing the opportunity to donors to give knowledge in addition to blood can result in production of high value biomedical data. Giving blood, being a public health actor. Key messages Blood donors may provide knowledge and bioresources in addition to blood products. Blood donors in France have enabled several large-scale epidemiological studies.

Dates et versions

hal-03758813 , version 1 (23-08-2022)

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Citer

P Tiberghien, P Gallian, P Morel, D Bougard, J Chiaroni, et al.. Giving blood: providing treatment, providing knowledge. European Journal of Public Health, 2019, 29 (Supplement_4), ⟨10.1093/eurpub/ckz186.013⟩. ⟨hal-03758813⟩
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