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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2016

FtsK translocation permits discrimination between an endogenous and an imported Xer/ dif recombination complex

Florian Fournes
  • Fonction : Auteur
Estelles Crozat
  • Fonction : Auteur
Carine Pages
  • Fonction : Auteur
Catherine Tardin
  • Fonction : Auteur
François Cornet
Philippe Rousseau

Résumé

Significance This study focuses on a molecular machine (Xer/ dif /FtsK) involved in circular chromosome processing during the bacterial cell cycle. Xer site-specific recombinases are well known to act at the chromosomal dif (dimer resolution) sites for chromosome dimer resolution (CDR). The Xer/ dif recombination machine is, however, highly versatile and is also implicated in integration and excision of mobile genetic elements (MGE). Whereas CDR depends on the FtsK DNA translocase, MGE mobility somehow escapes this control. Focusing on the case of the gonococcal genetic island found in pathogenic Neisseria species, we reveal how FtsK distinguishes a Xer/ dif complex involved in vertical genetic transfer (CDR) from one involved in horizontal gene transfer (MGE mobility).

Dates et versions

hal-03741739 , version 1 (01-08-2022)

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Citer

Florian Fournes, Estelles Crozat, Carine Pages, Catherine Tardin, Laurence Salomé, et al.. FtsK translocation permits discrimination between an endogenous and an imported Xer/ dif recombination complex. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (28), pp.7882-7887. ⟨10.1073/pnas.1523178113⟩. ⟨hal-03741739⟩
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