Article Dans Une Revue Science Advances Année : 2020

Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features

Résumé

Bone is built from collagen fibrils and biomineral nanoparticles. In humans, they are organized in lamellar twisting patterns on the microscale. It has been a central tenet that the biomineral nanoparticles are co-aligned with the bone nanostructure. Here, we reconstruct the three-dimensional orientation in human lamellar bone of both the nanoscale features and the biomineral crystal lattice from small-angle x-ray scattering and wide-angle x-ray scattering, respectively. While most of the investigated regions show well-aligned nanostructure and crystal structure, consistent with current bone models, we report a localized difference in orientation distribution between the nanostructure and the biomineral crystals in specific bands. Our results show a robust and systematic, but localized, variation in the alignment of the two signals, which can be interpreted as either an additional mineral fraction in bone, a preferentially aligned extrafibrillar fraction, or the result of transverse stacking of mineral particles over several fibrils.

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hal-03727365 , version 1 (19-07-2022)

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Tilman A. Grunewald, Marianne Liebi, Nina K. Wittig, Andreas Johannes, Tanja Sikjaer, et al.. Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features. Science Advances , 2020, 6 (24), pp.eaba4171-1-eaba4171-7. ⟨10.1126/sciadv.aba4171⟩. ⟨hal-03727365⟩

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