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Poster De Conférence Année : 2022

Effect of ageing on the cerebral hemodynamics in the marmoset monkey

Résumé

Aim Cerebrovascular function declines during normal ageing and appears to be closely linked to brain function alteration in the elderly. We adapted dedicated MRI sequences to analyze blood flow dynamics in arterial and venous intracranial vessels, using a non-human primate model of significant interest for preclinical research, the marmoset monkey Callithrix jacchus. Methods Imaging sequences were acquired on a 7T MRI (Bruker Biospec, voxel size: 0,15x0,15X1mm3) on two groups of male and female marmosets: 10 young (4 years old) and 9 aged (9 years old). Internal carotid arteries, basilar artery, superior and inferior sagittal sinuses were first identified by Time Of Flight (TOF) sequences and flow velocity in these different vessels was recorded by Phase Contrast (PC) MRI synchronized with ECG signal. Results The main significant results show that during the cardiac cycle: -The blood flow peaks earlier in the basilary trunk than in the carotids. -The arterial flow peak occurs earlier in the aged than in the young marmoset brains. -The time interval between the arterial- and the venous flow peaks is shorter in old than in young marmosets. Conclusions These results reflect vessel rigidity and tissue compliance changes occurring during ageing in the vascular network. They have not been shown in human studies, in which blood flow dynamics are usually synchronized with peripheral pulse measured on the fingertip. They suggest that the time courses of the different vascular flows could contribute as early markers of brain ageing and brain pathologies.
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Dates et versions

hal-03726406 , version 1 (18-07-2022)

Identifiants

  • HAL Id : hal-03726406 , version 1

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Caroline Fonta, Germain Arribarat, Muriel Mescam, Franck Desmoulin. Effect of ageing on the cerebral hemodynamics in the marmoset monkey. FENS Forum 2022, Jul 2022, Paris, France. ⟨hal-03726406⟩
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